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Shaun Murphy: is a young surgeon with autism. His savant abilities include near-photographic recall and the ability to note minute details and changes.
Played by: Freddie Highmore
Claire Browne : A surgical resident who forms a special connection with Shaun.
Played by: Antonia Thomas
Neil Melendez: A Cardiothoracic surgeon in charge of surgical resident. He is engaged to Jessica Preston.
Played by: Nicholas Gonzalez
Aaron Glassman: President of the Bonaventure Hospital. He is Shaun's mentor.
Played by: Richard Schiff
Jessica Preston: She is the hospital house Attorney and Vice President of Risk Management. She is engaged to Neil.
Played by: Beau Garrett
Andrews Marcus: He is the Chief of Surgery and Board member.
Played by: Hill Harper
Allegra Aoki: Chairman and Vice President of the hospital.
Played by: Tamlyn Tomita