Derek Shepherd

Played by Patrick Dempsey

Head of Neurosurgery at Grey-Sloan Memorial

Divorced from Addison Montgomery-Shepherd in Season 3

Had an on and off relationship with Meredith Grey from Season 1-Season 5

Married Grey at the end of Season 5

Has four sisters: Nancy, Kathleen, Liz, and Amelia

Was in a plane crash in Season 8 that almost cost him his hand