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The focus of the lab
The My research focuses on cancer genetics, specifically on a class of genes that are known as tumor suppressor genes. Currently work on in my laboratory focuses on the von Hippel-Lindau (VHL) gene. Investigations are centered on uncovering the normal functions of this gene and learning how mutations in it can cause cancer.
tumor suppressor genes?
Cellular approach to cancer
Most tumors are clonal outgrowths of a single malignant cell. In my lab, we study the earliest events in cancer that cause these single cells to lose their normal growth control. The approach taken consists of a blend of cell biology, genetics, and molecular biology. Some of the student projects involve creating and expressing mutant VHL proteins and determining their effects in cells. We are also utilizing RNA interference to block the expression of specific genes and then analyzing the cellular effects. Specific techniques that are learned and utilized in my lab include Western blotting, immunoprecipitation, microscopy (including immunofluorescence), molecular cloning (PCR, restriction digests, etc.), and cell culture (transfection and retroviral infection, selection, growth assays, DNA damage assays, and more).
Currently, my lab has a number of undergraduate and graduate (Master’s level) students who carry out the bulk of the research (with a little help from me) either on a volunteer basis or for course credit. My lab is open to Adelphi students in the biology program, following my approval. (If you are not currently an Adelphi undergraduate biology major or in our graduate (M.S.) biology program and want to find out more about these programs, please click on the links). Because space is limited, I am looking for students who are sincerely interested in performing research and are willing to commit the time and energy necessary to succeed.
last modified on 6-23-11